Functional Defects Caused by Glaucoma – Associated Mutations in Optineurin
نویسندگان
چکیده
Glaucomas are a heterogeneous group of optic neuropathies characterized by progressive loss of retinal ganglion cells (RGCs) leading to visual field defects. The distinctive pattern of optic nerve degeneration results in glaucomatous cupping. The atrophy of optic nerve cells initially leads to loss of peripheral vision and visual field loss increases with increased dam‐ age to optic nerve. Worldwide glaucoma is the second leading cause of blindness affecting more than 70 million people [1, 2]. Traditionally elevated intraocular pressure (IOP) is con‐ sidered as a major risk factor for glaucomatous neuropathy. In addition to increased IOP, other risk factors include age, genetic and environmental factors, myopia, primary vascular dysregulation and hypertension [3, 4].
منابع مشابه
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